Extended in vivo blood circulation time of fluorinated liposomes

FEBS Letters

Santaella, Catherine¹  Vierling, Pierre¹  Frézard, Frédéric¹  Riess, Jean G.¹ 

[1] Laboratoire de Chimie Moléculaire, URA 426 au CNRS, Faculté des Sciences, Université de Nice-Sophia Antipolis, 06108 Nice Cédex 02, France

关键词: Fluorinated liposome;    Fluorinated membrane;    Blood clearance;    Circulation half-life;    Lipophobicity;    Intravascular persistence;   

DOI  :  10.1016/0014-5793(93)80860-W

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The clearance from blood circulation of fluorinated liposomes made with perfluoroalkylated phosphatidylcholines was investigated in mice using liposome-entrapped 5(6)-carboxyfluorescein. The presence of a fluorinated core inside the membrane strongly retards their blood clearance. The fluorinated vesicles showed circulation half-lives of up to 8.6 h, which are 6–13 and 3–6 times larger than those of similarly sized conventional distearoylphosphatidylcholine and distearoylphosphatidylcholine/cholesterol liposomes, respectively. Their blood clearance was similar to that of some polyethylene glycol (PEG)-labelled ‘stealth’ liposomes and was dose-independent in a 3.3–330 body weight dose range.

【 授权许可】

Unknown