Stability of liposomes in circulation is markedly enhanced by structural modification of their phospholipid component

FEBS Letters

Gupta, C.M.¹  Dhawan, S.¹  Bali, A.¹ 

[1] Division of Biophysics, Central Drug Research Institute, Lucknow-226001, India

关键词: Drug delivery;    Modified liposomes;    Plasma-induced leakage;    Lipid transfer;    Blood clearance;    Tissue uptake;    PC;    phosphatidylcholine;    MPC;    1-pal mitoyl-2-heptadec-10-cis-enylcarbamyloxy-sn-glycero-3-phosphorylcholine;    CH;    cholesterol;    6-CF;    6-carboxyfluorescein;    HDL;    high density fraction of plasma lipoproteins;   

DOI  :  10.1016/0014-5793(83)80185-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Replacement of the C-2 ester group in phosphatidylcholine by the carbamyloxy function rendered its liposomes completely stable and longer living in the circulation of rats.

【 授权许可】

Unknown