Chronic obstructive pulmonary disease does not impair responses to resistance training

Journal of Translational Medicine

Rafi Ahmad¹  Morten Grundtvig²  Marita Hanestadhaugen³  Lise Koll³  Truls Raastad⁴  Tore Jørgen Rødølen⁵  Roger Lien⁵  Bente Malerbakken⁶  Knut Sindre Mølmen⁷  Daniel Hammarström⁷  Bent R. Rønnestad⁷  Gunnar Slettaløkken Falch⁷  Yusuf Khan⁸  Stian Ellefsen⁹ 

[1] Department of Biotechnology, Inland Norway University of Applied Sciences, Hamar, Norway;Institute of Clinical Medicine, Faculty of Health Sciences, UiT – The Arctic University of Norway, Tromsø, Norway;Department of Medicine, Innlandet Hospital Trust, Lillehammer, Norway;Department of Pathology, Innlandet Hospital Trust, Lillehammer, Norway;Department of Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway;Innlandet Hospital Trust, Granheim Lung Hospital, Follebu, Norway;Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway;Section for Health and Exercise Physiology, Inland Norway University of Applied Sciences, P.O. Box 422, 2604, Lillehammer, Norway;Section for Health and Exercise Physiology, Inland Norway University of Applied Sciences, P.O. Box 422, 2604, Lillehammer, Norway;Department of Biotechnology, Inland Norway University of Applied Sciences, Hamar, Norway;Section for Health and Exercise Physiology, Inland Norway University of Applied Sciences, P.O. Box 422, 2604, Lillehammer, Norway;Innlandet Hospital Trust, Lillehammer, Norway;

关键词: Anabolic resistance;    COPD;    Pathophysiology;    Skeletal muscle;    Strength training;    Training load;   

DOI  :  10.1186/s12967-021-02969-1

来源: Springer

【 摘 要 】

BackgroundSubjects with chronic obstructive pulmonary disease (COPD) are prone to accelerated decay of muscle strength and mass with advancing age. This is believed to be driven by disease-inherent systemic pathophysiologies, which are also assumed to drive muscle cells into a state of anabolic resistance, leading to impaired abilities to adapt to resistance exercise training. Currently, this phenomenon remains largely unstudied. In this study, we aimed to investigate the assumed negative effects of COPD for health- and muscle-related responsiveness to resistance training using a healthy control-based translational approach.MethodsSubjects with COPD (n = 20, GOLD II-III, FEV1predicted 57 ± 11%, age 69 ± 5) and healthy controls (Healthy, n = 58, FEV1predicted 112 ± 16%, age 67 ± 4) conducted identical whole-body resistance training interventions for 13 weeks, consisting of two weekly supervised training sessions. Leg exercises were performed unilaterally, with one leg conducting high-load training (10RM) and the contralateral leg conducting low-load training (30RM). Measurements included muscle strength (nvariables = 7), endurance performance (nvariables = 6), muscle mass (nvariables = 3), muscle quality, muscle biology (m. vastus lateralis; muscle fiber characteristics, RNA content including transcriptome) and health variables (body composition, blood). For core outcome domains, weighted combined factors were calculated from the range of singular assessments.ResultsCOPD displayed well-known pathophysiologies at baseline, including elevated levels of systemic low-grade inflammation ([c-reactive protein]serum), reduced muscle mass and functionality, and muscle biological aberrancies. Despite this, resistance training led to improved lower-limb muscle strength (15 ± 8%), muscle mass (7 ± 5%), muscle quality (8 ± 8%) and lower-limb/whole-body endurance performance (26 ± 12%/8 ± 9%) in COPD, resembling or exceeding responses in Healthy, measured in both relative and numeric change terms. Within the COPD cluster, lower FEV1predicted was associated with larger numeric and relative increases in muscle mass and superior relative improvements in maximal muscle strength. This was accompanied by similar changes in hallmarks of muscle biology such as rRNA-content↑, muscle fiber cross-sectional area↑, type IIX proportions↓, and changes in mRNA transcriptomics. Neither of the core outcome domains were differentially affected by resistance training load.ConclusionsCOPD showed hitherto largely unrecognized responsiveness to resistance training, rejecting the notion of disease-related impairments and rather advocating such training as a potent measure to relieve pathophysiologies.Trial registration: ClinicalTrials.gov ID: NCT02598830. Registered November 6th 2015, https://clinicaltrials.gov/ct2/show/NCT02598830

【 授权许可】

CC BY