Apolipoproteins A1 and B and their ratio in acute ischemic stroke patients with intracranial and extracranial arterial stenosis: an Egyptian study

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

article

Fahmy, Ebtesam Mohammed¹  El Awady, Mohammed Ahmed El Sayed¹  Sharaf, Sahar Abdel-Atty²  Selim, Nora Mahmoud²  Abdo, Hazem El Sawy¹  Mohammed, Shaimaa Shaheen¹ 

[1] Neurology Department, Faculty of Medicine, Cairo University;Clinical pathology Department, Faculty of Medicine, Cairo University

关键词: Apolipoprotein A1;    Apolipoprotein B;    Atherosclerosis;    Intracranial stenosis;    Extracranial stenosis;   

DOI  :  10.1186/s41983-020-00245-5

学科分类：医学（综合）

来源: Springer

【 摘 要 】

Apolipoprotein A1 and B and their ratio are considered a better biomarker for cardiovascular diseases than a lipid profile, but this previous finding is not proved to cerebrovascular ischemic diseases. The aim of this study is to assess the relation between apolipoprotien A1 and B and their ratio to intra- and extracranial carotid atherosclerosis in patients with ischemic acute stroke. 90 Egyptian patients with acute ischemic stroke are included in the study, and they have been classified into 3 groups: group 1 includes 30 patients with intracranial stenosis, group 2 includes 30 patients with extracranial arterial stenosis, and group 3 includes 30 patients with non-arterial stenosis. Patients were subjected to clinical assessment, routine laboratory measures, and Color-Coded Duplex Sonography for extracranial and intracranial arteries. The measurement of serum levels of apolipoproteins A1 and B was done using enzyme-linked immuno-sorbent assay (ELISA). A statistically significant difference was found between patient groups as regards the frequency of abnormal serum LDL-cholesterol (p = 0.04), being elevated in patients with extracranial stenosis (p = 0.01). There was a significant difference between patients groups as regards the frequency of abnormal serum HDL-cholesterol (p = 0.02), being lower in patients with extracranial stenosis. High Apo B/A1 ratio was an independent risk factor for intracranial arterial stenosis (p = 0.045). An abnormal elevation of serum LDL cholesterol was an independent risk factor of extracranial arterial stenosis (p = 0.021). Apo B/A1 ratio is an independent risk factor for intracranial arterial stenosis, while serum LDL cholesterol is an independent risk factor for extracranial arterial stenosis. Apo B/A1 ratio and serum LDL cholesterol are reliable serum biomarkers for cranial arterial stenosis in acute ischemic stroke patients.

【 授权许可】

CC BY