LncRNA-mediated posttranslational modifications and reprogramming of energy metabolism in cancer

Cancer Communications

article

Yue-Tao Tan¹  Jin-Fei Lin¹  Ting Li¹  Jia-Jun Li¹  Rui-Hua Xu¹  Huai-Qiang Ju¹ 

[1] Department of Medical Oncology, Sun Yat-sen University Cancer Center;State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine;These authors contributed equally to this work.;Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences

关键词: cancer metabolism;    enzyme;    long noncoding RNA;    metabolic reprogramming;    posttranslational modification;   

DOI  :  10.1002/cac2.12108

学科分类：社会科学、人文和艺术（综合）

来源: Springer

【 摘 要 】

Altered metabolism is a hallmark of cancer, and the reprogramming of energy metabolism has historically been considered a general phenomenon of tumors. It is well recognized that long noncoding RNAs (lncRNAs) regulate energy metabolism in cancer. However, lncRNA-mediated posttranslational modifications and metabolic reprogramming are unclear at present. In this review, we summarized the current understanding of the interactions between the alterations in cancer-associated energy metabolism and the lncRNA-mediated posttranslational modifications of metabolic enzymes, transcription factors, and other proteins involved in metabolic pathways. In addition, we discuss the mechanisms through which these interactions contribute to tumor initiation and progression, and the key roles and clinical significance of functional lncRNAs. We believe that an in-depth understanding of lncRNA-mediated cancer metabolic reprogramming can help to identify cellular vulnerabilities that can be exploited for cancer diagnosis and therapy.

【 授权许可】

CC BY|CC BY-NC-ND