Regulation of Metabolic Reprogramming by Long Non-Coding RNAs in Cancer

Cancers

Cesar A. Martinez¹  Pasquale Saggese¹  Claudio Scafoglio¹  Giovanni Pecoraro²  Giorgio Giurato²  Roberta Tarallo²  Assunta Sellitto²  Francesca Rizzo²  Giovanni Nassa² 

[1] Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA;Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry ‘Scuola Medica Salernitana’, University of Salerno, 84081 Baronissi, Italy;

关键词: cancer metabolism;    long non-coding RNAs;    metabolic reprogramming;    glycolysis;    Warburg effect;    glutaminolysis;   

DOI  :  10.3390/cancers13143485

来源: DOAJ

【 摘 要 】

Metabolic reprogramming is a well described hallmark of cancer. Oncogenic stimuli and the microenvironment shape the metabolic phenotype of cancer cells, causing pathological modifications of carbohydrate, amino acid and lipid metabolism that support the uncontrolled growth and proliferation of cancer cells. Conversely, metabolic alterations in cancer can drive changes in genetic programs affecting cell proliferation and differentiation. In recent years, the role of non-coding RNAs in metabolic reprogramming in cancer has been extensively studied. Here, we review this topic, with a focus on glucose, glutamine, and lipid metabolism and point to some evidence that metabolic alterations occurring in cancer can drive changes in non-coding RNA expression, thus adding an additional level of complexity in the relationship between metabolism and genetic programs in cancer cells.

【 授权许可】

Unknown