Small leucine rich proteoglycans in host immunity and renal diseases

Journal of Cell Communication and Signaling

article

Zou, Wei¹  Wan, Junhui²  Li, Min²  Xing, Juanjuan³  Chen, Qi²  Zhang, Zhi²  Gong, Yi² 

[1] Department of Infectious Diseases, The 1st Affiliated Hospital of Nanchang University;Department of Gynecology and Obstetrics, The 1st Affiliated Hospital of Nanchang University;Department of Burn, The 1st Affiliated Hospital of Nanchang University

关键词: SLRPs;    TLR 2/4;    Host immunity;    Renal diseases;   

DOI  :  10.1007/s12079-018-0489-8

学科分类：分子生物学，细胞生物学和基因

来源: Springer

【 摘 要 】

The small leucine rich proteoglycans (SLRPs), structurally consisting of protein cores and various glycosaminoglycan side chains, are grouped into five classes based on common structural and functional properties. Besides being an important structural component of extracellular matrix (ECM), SLRPs have been implicated in the complex network of signal transduction and host immune responses. The focus of this review is on SLRPs in host immunity. Because host immunity plays an important part in the pathogenesis of renal diseases, the role of SLRPs in this set of diseases will also be discussed.

【 授权许可】

CC BY