Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
Toll‐like receptor 2/4 links to free fatty acid‐induced inflammation and β‐cell dysfunction | |
关键词: TLR 2/4; FFA; apoptosis; type 2 diabetes; autophagy; | |
DOI : 10.1189/jlb.0313143 | |
学科分类:生理学 | |
来源: Federation of American Societies for Experimental Biology | |
【 摘 要 】
T2Disametabolicandinflammatorydiseasecharacterizedbydeterioratingβ‐cellfunctionandincreasedlevelsofinflammatorycytokines.Low‐gradeinflammationandinnateimmunesystemactivationleadtoβ‐cellfailure.Recently,SFAshavebeenproposedastriggersofmetabolism‐associatedinflammationthroughtheTLRfamilyofPRRs.Inthisreview,recentprogressindefiningthemolecularbasisofFFA‐associatedTLR2/4activationandsignalinginβ‐celldysfunctionandapoptosisissummarized.Furthermore,wehighlightlinksbetweenTLRsanddiabeticcomplications,insulinresistance,andautophagy.ThisknowledgemayfacilitatenovelstrategiestoabrogateinflammationinT2D...
【 授权许可】
CC BY
【 预 览 】
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RO201901232418164ZK.pdf | 272KB | download |