期刊论文详细信息
| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Toll‐like receptor 2/4 links to free fatty acid‐induced inflammation and β‐cell dysfunction | |
| 关键词: TLR 2/4; FFA; apoptosis; type 2 diabetes; autophagy; | |
| DOI : 10.1189/jlb.0313143 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
T2Disametabolicandinflammatorydiseasecharacterizedbydeterioratingβ‐cellfunctionandincreasedlevelsofinflammatorycytokines.Low‐gradeinflammationandinnateimmunesystemactivationleadtoβ‐cellfailure.Recently,SFAshavebeenproposedastriggersofmetabolism‐associatedinflammationthroughtheTLRfamilyofPRRs.Inthisreview,recentprogressindefiningthemolecularbasisofFFA‐associatedTLR2/4activationandsignalinginβ‐celldysfunctionandapoptosisissummarized.Furthermore,wehighlightlinksbetweenTLRsanddiabeticcomplications,insulinresistance,andautophagy.ThisknowledgemayfacilitatenovelstrategiestoabrogateinflammationinT2D...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904048048259ZK.pdf | 272KB |  download |
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