The loopy world of cohesin

eLife

Shiori Iida¹  Kazuhiro Maeshima¹ 

[1] Genome Dynamics Laboratory, National Institute of Genetics, Mishima, Japan;Department of Genetics, School of Life Sciences, Sokendai (Graduate University for Advanced Studies), Mishima, Japan;

关键词: cohesin;    smc complexes;    sister chromatid cohesion;    DNA loop extrusion;    structural biology;    biophysical simulation;    Human;    S. cerevisiae;    S. pombe;   

DOI  :  10.7554/eLife.71585

来源: eLife Sciences Publications, Ltd

【 摘 要 】

DNA loops can be formed by a mechanism in which the cohesin complex pulls DNA strands through its ring structure using biased Brownian motion.

【 授权许可】

CC BY