Dual-Wavelength Photosensitive Nano-in-Micro Scaffold Regulates Innate and Adaptive Immune Responses for Osteogenesis

Nano-Micro Letters

Yin Xiao¹  Hua Tang²  Jinyang Wang³  Chengcheng Yin³  Qin Zhao³  Zifan Zhao³  Kailun Shen³  Jinglun Zhang³  Miusi Shi³  Yufeng Zhang⁴  Lingling Zhang⁴ 

[1] Institute of Health and Biomedical Innovation & Australia-China Centre for Tissue Engineering and Regenerative Medicine, Queensland University of Technology, 4059, Kelvin Grove, QLD, Australia;Institute of Immunology, Shandong First Medical University & Shandong Academy of Medical Sciences, 271000, Taian, People’s Republic of China;The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine, Ministry of Education, School and Hospital of Stomatology, Wuhan University, 430079, Wuhan, People’s Republic of China;The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine, Ministry of Education, School and Hospital of Stomatology, Wuhan University, 430079, Wuhan, People’s Republic of China;Medical Research Institute, School of Medicine, Wuhan University, 430071, Wuhan, People’s Republic of China;

关键词: Gold nanocage;    Drug release;    Photocatalysis;    Immunomodulation;    Osteoinduction;   

DOI  :  10.1007/s40820-020-00540-z

来源: Springer

【 摘 要 】

tsThe controlled release of IL-4 and dexamethasone by a dual-wavelength photosensitive nano-in-micro scaffold (biphasic calcium phosphate loaded with goad nanocage, BCP-GNC) enables the regulation of specific immune cells and immune responses.BCP-GNC regulates innate and adaptive immune responses in two stages (directing the M2 polarization of macrophages and inhibiting the maturation of dendritic cells) to promote osteoinduction.

【 授权许可】

CC BY