Properties of an Oral Preparation Containing a Chitosan Salt

Molecules

Yoshifumi Murata¹  Youko Kodama²  Daijirou Hirai²  Kyouko Kofuji² 

[1] Faculty of Pharmaceutical Science, Hokuriku University, Ho-3, Kanagawa-machi, Kanazawa 920-1181, Japan; E-mails

关键词: Chitosan;    2-(4-Chlorophenoxy)-2-methylpropionic acid;    Bile acid adsorption;    Drug release;    Hyperlipidemia.;   

DOI  :  10.3390/molecules14020755

来源: mdpi

【 摘 要 】

The 2-(4-chlorophenoxy)-2-methylpropionic acid (CMP) salt of chitosan (CS), CS-CMP, and that of a CS derivative (CP), were prepared and their ability to adsorb bile acids investigated. CS-CMP and CP-CMP rapidly adsorbed taurocholate (TCA) and glycocholate (GCA) when these bile acids were present together in the medium, with simultaneous release of CMP. A secondary bile acid, taurodeoxycholate, was preferentially adsorbed over TCA and GCA. Alginate gel beads containing CS-CMP did not differ from CS-CMP alone in their manner of bile acids take up. Furthermore, oral administration of CS-CMP to rats resulted in decreased serum cholesterol and triacylglycerol levels for two weeks. Therefore, CS-CMP, as well as a vehicle containing CS-CMP, might be a useful agent with which to treat hyperlipidemia.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.