Roles of lysine-specific demethylase 1 (LSD1) in homeostasis and diseases

Journal of Biomedical Science

Sung Hee Baek¹  Dongha Kim²  Keun Il Kim³ 

[1] Creative Research Initiatives Center for Epigenetic Code and Diseases, Department of Biological Sciences, Seoul National University, 08826, Seoul, Republic of Korea;Department of Anatomy, College of Medicine, The Catholic University of Korea, 06591, Seoul, Republic of Korea;Department of Biological Sciences, Sookmyung Women’s University, 04310, Seoul, Republic of Korea;

关键词: Cancer;    Hypoxia;    Inflammation;    Immunity;    Neurodegenerative diseases;   

DOI  :  10.1186/s12929-021-00737-3

来源: Springer

【 摘 要 】

Lysine-specific demethylase 1 (LSD1) targets mono- or di-methylated histone H3K4 and H3K9 as well as non-histone substrates and functions in the regulation of gene expression as a transcriptional repressor or activator. This enzyme plays a pivotal role in various physiological processes, including development, differentiation, inflammation, thermogenesis, neuronal and cerebral physiology, and the maintenance of stemness in stem cells. LSD1 also participates in pathological processes, including cancer as the most representative disease. It promotes oncogenesis by facilitating the survival of cancer cells and by generating a pro-cancer microenvironment. In this review, we discuss the role of LSD1 in several aspects of cancer, such as hypoxia, epithelial-to-mesenchymal transition, stemness versus differentiation of cancer stem cells, as well as anti-tumor immunity. Additionally, the current understanding of the involvement of LSD1 in various other pathological processes is discussed.

【 授权许可】

CC BY