Recent advances and prospects of hyaluronan as a multifunctional therapeutic system

JOURNAL OF CONTROLLED RELEASE

卷:336

Review

Kotla, Niranjan G.¹  Bonam, Srinivasa Reddy²  Rasala, Swetha¹  Wankar, Jitendra¹  Bohara, Raghvendra A.¹  Bayry, Jagadeesh^2,3  Rochev, Yury^1,4  Pandit, Abhay¹ 

[1] Natl Univ Ireland, SFI Res Ctr Med Devices, CURAM, Galway H91 W2TY, Ireland

[2] Univ Paris, Sorbonne Univ, Ctr Rech Cordeliers Equipe Immunopathol & Immunoi, Inst Natl Sante & Rech Med, F-75006 Paris, France

[3] Indian Inst Technol Palakkad, Palakkad 678623, Kerala, India

[4] Sechenov First Moscow State Med Univ, Inst Regenerat Med, Moscow 119992, Russia

关键词: Hyaluronic acid;    Low and high molecular weight HA;    Drug delivery;    Inflammation;    Immunity;    Cancer;   

DOI  :  10.1016/j.jconrel.2021.07.002

来源: Elsevier

【 摘 要 】

Hyaluronan (HA) is a naturally occurring non-sulfated glycosaminoglycan (GAG), cell-surface-associated biopolymer and is the key component of tissue extracellular matrix (ECM). Along with remarkable physicochemical properties, HA also has multifaceted biological effects that include but not limited to ECM organization, immunomodulation, and various cellular processes. Environmental cues such as tissue injury, infection or cancer change downstream signaling functionalities of HA. Unlike native HA, the fragments of HA have diversified effects on inflammation, cancer, fibrosis, angiogenesis and autoimmune response. In this review, we aim to discuss HA as a therapeutic delivery system development process, source, biophysical-chemical properties, and associated biological pathways (especially via cell surface receptors) of native and fragmented HA. We also tried to address an overview of the potential role of HA (native HA vs fragments) in the modulation of inflammation, immune response and various cancer targeting delivery applications. This review will also highlight the HA based therapeutic systems, medical devices and future perspectives of various biomedical applications were discussed in detail.

【 授权许可】

Free