Frontiers in Medicine | |
Humoral and Cellular Response of Frontline Health Care Workers Infected by SARS-CoV-2 in Nice, France: A Prospective Single-Center Cohort Study | |
Caroline Ruetsch1  Sylvia Benzaken1  Elisa Demonchy2  Marion Cremoni3  Vincent Esnault4  Barbara Seitz-Polski5  Carole Ichai6  Vesna Brglez7  Céline Fernandez7  Kévin Zorzi7  Sonia Boyer-Suavet7  Jean Dellamonica8  | |
[1] Laboratoire d'Immunologie, CHU de Nice, Université Côte d'Azur, Nice, France;Service d'Infectiologie, CHU de Nice, Université Côte d'Azur, Nice, France;Service de Néphrologie-Dialyse-Transplantation, CHU de Nice, Université Côte d'Azur, Nice, France;Unité de Recherche Clinique de la Côte d'Azur (UR2CA), Université Côte d'Azur, Nice, France;Service de Néphrologie-Dialyse-Transplantation, CHU de Nice, Université Côte d'Azur, Nice, France;Unité de Recherche Clinique de la Côte d'Azur (UR2CA), Université Côte d'Azur, Nice, France;Centre de Référence Maladies Rares Syndrome Néphrotique Idiopathique, CHU de Nice, Université Côte d'Azur, Nice, France;Service de Néphrologie-Dialyse-Transplantation, CHU de Nice, Université Côte d'Azur, Nice, France;Unité de Recherche Clinique de la Côte d'Azur (UR2CA), Université Côte d'Azur, Nice, France;Laboratoire d'Immunologie, CHU de Nice, Université Côte d'Azur, Nice, France;Centre de Référence Maladies Rares Syndrome Néphrotique Idiopathique, CHU de Nice, Université Côte d'Azur, Nice, France;Service de Réanimation Médicochirurgicale, CHU de Nice, Université Côte d'Azur, Nice, France;Unité de Recherche Clinique de la Côte d'Azur (UR2CA), Université Côte d'Azur, Nice, France;Centre de Référence Maladies Rares Syndrome Néphrotique Idiopathique, CHU de Nice, Université Côte d'Azur, Nice, France;Unité de Recherche Clinique de la Côte d'Azur (UR2CA), Université Côte d'Azur, Nice, France;Service de Réanimation Médicale, CHU de Nice, Université Côte d'Azur, Nice, France; | |
关键词: health care workers; SARS-CoV-2; COVID-19; humoral response; cellular response; blood immune biomarkers; | |
DOI : 10.3389/fmed.2020.608804 | |
来源: Frontiers | |
【 摘 要 】
Frontline health care workers (HCWs) have been particularly exposed to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) since the start of the pandemic but the clinical features and immune responses of those infected with SARS-CoV-2 have not been well described. In a prospective single center cohort study, we enrolled 196 frontline HCWs exposed to the SARS-Cov-2 and 60 patients with moderate and severe forms of the coronavirus disease 2019 (COVID-19). Serological tests and cytokines assay were performed to analyze SARS-CoV-2-specific humoral and cellular immunity. Of the 196 HCWs tested, 15% had specific antibodies against SARS-CoV-2 and 45% of seropositive HCWs were strictly asymptomatic. However, in comparison to moderate and severe forms, HCWs with mild or asymptomatic forms of COVID-19 showed lower specific IgA and IgG peaks, consistent with their mild symptoms, and a robust immune cellular response, illustrated by a high production of type I and II interferons. Further studies are needed to evaluate whether this interferon functional immune assay, routinely applicable, can be useful in predicting the risk of severe forms of COVID-19.
【 授权许可】
CC BY
【 预 览 】
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