Magnetic nanoparticles for cancer therapy

Nanotechnology Reviews

article

Stephan Dürr¹  Christina Janko¹  Stefan Lyer¹  Philipp Tripal¹  Marc Schwarz¹  Jan Zaloga¹  Rainer Tietze¹  Christoph Alexiou¹ 

[1] Department of Otorhinolaryngology, Section for Experimental Oncology and Nanomedicine (SEON), University Hospital Erlangen

关键词: cancer drug resistance;    cancer therapy;    drug delivery;    hyperthermia;    magnetic nanoparticles;   

DOI  :  10.1515/ntrev-2013-0011

学科分类：社会科学、人文和艺术（综合）

来源: De Gruyter

【 摘 要 】

Cancer is one of the biggest challenges facing the medical research in our time. The goals are to improve not only the therapeutic outcome, even in the cases of advanced and metastatic cancer, but also the methods of treatment, which often have considerable adverse effects. In addition, the current developments, such as demographic change, population growth, and increasing healthcare costs, have to be taken into consideration. In all likelihood, nanotechnology and, in particular, the use of magnetic nanoparticles consisting of the elements nickel, cobalt, and iron can make a significant contribution. The greatest potential can be ascribed to the drug delivery systems: magnetic nanoparticles are functionalized by binding them to various substances, including chemotherapeutic agents, radionuclides, nucleic acids, and antibodies. They can then be guided and accumulated using a magnetic field. Hyperthermia can be induced with an alternating magnetic field, providing another therapeutic option. Magnetic nanoparticles may be useful in overcoming cancer drug resistance. They also contribute to realizing a combination of diagnostic investigation and therapy in the field of “theranostics”. The multifaceted and promising results of research in the recent years offer the prospect of a real advance in cancer therapy in the near future.

【 授权许可】

CC BY