Magnetic Gel Composites for Hyperthermia Cancer Therapy

Gels

Marleen Häring¹  Jana Schiller¹  Judith Mayr¹  Santiago Grijalvo²  Ramon Eritja²  David D໚z D໚z¹ 

[1] Institut für Organische Chemie, Universität Regensburg, Universitätsstr. 31, Regensburg 93040, Germany; E-Mails:;IQAC-CSIC, Jordi Girona 18-26, Barcelona 08034, Spain; E-Mails:

关键词: hydrogel;    composites;    magnetic nanoparticles;    hyperthermia;    cancer therapy;    drug delivery;   

DOI  :  10.3390/gels1020135

来源: mdpi

【 摘 要 】

Hyperthermia therapy is a medical treatment based on the exposition of body tissue to slightly higher temperatures than physiological (i.e., between 41 and 46 °C) to damage and kill cancer cells or to make them more susceptible to the effects of radiation and anti-cancer drugs. Among several methods suitable for heating tumor areas, magnetic hyperthermia involves the introduction of magnetic micro/nanoparticles into the tumor tissue, followed by the application of an external magnetic field at fixed frequency and amplitude. A very interesting approach for magnetic hyperthermia is the use of biocompatible thermo-responsive magnetic gels made by the incorporation of the magnetic particles into cross-linked polymer gels. Mainly because of the hysteresis loss from the magnetic particles subjected to a magnetic field, the temperature of the system goes up and, once the temperature crosses the lower critical solution temperature, thermo-responsive gels undergo large volume changes and may deliver anti-cancer drug molecules that have been previously entrapped in their networks. This tutorial review describes the main properties and formulations of magnetic gel composites conceived for magnetic hyperthermia therapy.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.