Magnetic Hyperthermia and Radiation Therapy: Radiobiological Principles and Current Practice †

Nanomaterials

SpiridonV. Spirou¹  Claudio Sangregorio²  Claudia Innocenti²  Alessandro Lascialfari³  Martina Basini³ 

[1] Department of Radiology, Sismanoglio General Hospital of Attica, Sismanogliou 1, Marousi 15126, Greece;ICCOM-CNR via Madonna del Piano 10, 50019 Sesto Fiorentino, Italy;Università degli Studi di Milano, Dipartimento di Fisica, Via Celoria 16, 20133 Milano, Italy;

关键词: hyperthermia;    radiation therapy;    magnetic nanoparticles;    magnetic fluid hyperthermia;    nanomedicine;    cancer therapy;   

DOI  :  10.3390/nano8060401

来源: DOAJ

【 摘 要 】

Hyperthermia, though by itself generally non-curative for cancer, can significantly increase the efficacy of radiation therapy, as demonstrated by in vitro, in vivo, and clinical results. Its limited use in the clinic is mainly due to various practical implementation difficulties, the most important being how to adequately heat the tumor, especially deep-seated ones. In this work, we first review the effects of hyperthermia on tissue, the limitations of radiation therapy and the radiobiological rationale for combining the two treatment modalities. Subsequently, we review the theory and evidence for magnetic hyperthermia that is based on magnetic nanoparticles, its advantages compared with other methods of hyperthermia, and how it can be used to overcome the problems associated with traditional techniques of hyperthermia.

【 授权许可】

Unknown