期刊论文详细信息
Nanotechnology Reviews
Smart mesoporous silica nanoparticles for controlled-release drug delivery
article
Mahdi Karimi1  Hamed Mirshekari2  Masoumeh Aliakbari3  Parham Sahandi-Zangabad4  Michael R. Hamblin5 
[1] Faculty of Advanced Technologies in Medicine, Department of Medical Nanotechnology, Iran University of Medical Sciences;Advanced Nanobiotechnology and Nanomedicine Research Group (ANNRG), Iran University of Medical Sciences;Medical Laboratory Sciences, Kerman University of Medical Science;Department of Materials Science and Engineering, Sharif University of Technology;Wellman Center for Photomedicine, Massachusetts General Hospital;Department of Dermatology, Harvard Medical School;Harvard-MIT Division of Health Sciences and Technology
关键词: drug delivery systems;    enzyme;    light-responsive nanocarriers;    magnetic;    mesoporous silica nanoparticles;    pH;    redox;    stimuli responsive;    temperature;   
DOI  :  10.1515/ntrev-2015-0057
学科分类:社会科学、人文和艺术(综合)
来源: De Gruyter
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【 摘 要 】

Stimuli-responsive controlled-release nanocarriers are promising vehicles for delivery of bioactive molecules that can minimize side effects and maximize efficiency. The release of the drug occurs when the nanocarrier is triggered by an internal or external stimulus. Mesoporous silica nanoparticles (MSN) can have drugs and bioactive cargos loaded into the high-capacity pores, and their release can be triggered by activation of a variety of stimulus-responsive molecular “gatekeepers” or “nanovalves.” In this mini-review, we discuss the basic concepts of MSN in targeted drug-release systems and cover different stimulus-responsive gatekeepers. Internal stimuli include redox, enzymes, and pH, while external stimuli include light, ultrasound, and magnetic fields, and temperature can either be internal or external.

【 授权许可】

CC BY   

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