An efficient synthesis of 2-substituted benzoxazoles using cerium(III) chloride/sodium iodide as catalyst

Heterocyclic communications

article

Xun Zhu¹  Yunyang Wei¹ 

[1] School of Chemical Engineering, Nanjing University of Science and Technology

关键词: cerium(III) chloride;    Lewis acid one-pot synthesis;    sodium iodide;    2-substituted benzoxazoles;   

DOI  :  10.1515/hc-2012-0054

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

An efficient and environmentally benign method for the synthesis of 2-substituted benzoxazoles is reported. The condensation of 2-aminophenol with an aldehyde gave an imine intermediate, which was cyclized and dehydrogenated to 2-substituted benzoxazole with good yield in the presence of CeCl 3 /NaI as catalyst. The one-pot synthesis was carried out in toluene at 100°C using O 2 as the oxidant.

【 授权许可】

CC BY|CC BY-NC-ND