Synthesis of 3,3-disubstituted oxindoles by organoselenium-induced radical cyclizations of N-arylacrylamides

Heterocyclic communications

article

Wei-jun Fu¹  Mei Zhu¹  Guang-long Zou² 

[1] College of Chemistry and Chemical Engineering, Luoyang Normal University;School of Chemistry and Enviromental Science

关键词: alkenes;    cyclization;    organoselenium;    oxindole;    radical cyclization;   

DOI  :  10.1515/hc-2014-0195

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

A simple and practical approach to oxindole derivatives via organoselenium-induced radical cyclizations of N -arylacrylamides has been developed. This method provides a convenient access to a variety of selenium-containing oxindoles in good to excellent yields under relatively mild reaction conditions. As one of its notable features, the radical process allows for the direct formation of a Se-C bond and the construction of a oxindole ring in one reaction.

【 授权许可】

CC BY|CC BY-NC-ND