Heterocyclization of 5,6-disubstituted 3-alkenyl-2-thioxothieno[2,3-d]pyrimidin-4-one with p-alkoxyphenyltellurium trichloride

Heterocyclic communications

article

Mykola Kut¹  Mikhajlo Onysko¹  Vasyl Lendel¹ 

[1] Organic Synthesis Laboratory, Uzhhorod National University

关键词: 3-alkenyl-2-thioxothieno[2;    3-d]pyrimidine-4-one;    [1;    3]thiazolo[3;    2-а]thieno[2;    3-d]pyrimidin-5-one;    electrophilic cyclization;    p-alkoxyphenyltellurium trichloride;    regioselectivity;   

DOI  :  10.1515/hc-2016-0169

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

Electrophilic heterocyclization of 5,6-disubstituted 3-alkenyl-2-thioxothieno[2,3- d ]pyrimidin-4-ones by treatment with p -alkoxyphenyltellurium trichlorides leads to annulation of the thiazoline moiety with the formation of 6,7-disubstituted-2-[dichloro-( p -alkoxyphenyl)telluromethyl]-2,3-dihydro-5 Н -[1,3]thiazolo[3,2- а ]thieno[2,3- d ]pyrimidin-5-one hydrochlorides.

【 授权许可】

CC BY|CC BY-NC-ND