Green-synthesized gold nanocubes functionalized with bisdemethoxycurcumin analog as an ideal anticancer candidate

Green Processing and Synthesis

article

Rajagopal Aruna Devi¹  Arul Prakash Francis¹  Thiyagarajan Devasena¹ 

[1] Centre for Nanoscience and Technology, A.C. Tech Campus, Anna University

关键词: BDMCA;    Costus pictus;    cytotoxicity;    gold nanocubes;    green synthesis;   

DOI  :  10.1515/gps-2013-0090

来源: De Gruyter

【 摘 要 】

Novel eco-friendly methods for the synthesis of metal nanoparticles are preferred and have recently been widely researched. In this study, a cost-effective and environmentally friendly method for the synthesis of gold nanoparticles was investigated. Costus pictus , also known as insulin plant due to its antidiabetic activity, was used as the reducing agent. Chloroaurate ions were rapidly reduced by the methanolic extract of Costus pictus , which was indicated by the color change from yellow to ruby red. The presence of a peak at 530 nm in UV-visible spectrophotometry confirmed the reduction of chloroaurate to gold nanoparticles. The reaction kinetics and effects of time, temperature, concentration of extract and substrate were also studied. The size and morphology of gold nanoparticles were analyzed using scanning electron microscopy (SEM) and high-resolution transmission electron microscopy (HR-TEM) and they were found to be cuboidal, with a size of around 20 nm. The size of the particles was also analyzed by the particle size analyzer, and was found to be 45 nm. These particles were functionalized with bisdemethoxycurcumin analog (BDMCA). X-ray diffraction (XRD) analysis of prepared nanoparticles showed that the gold nanoparticles have a face centered cubic structure and that of functionalized nanoparticles showed peaks similar to that of BDMCA. Fourier transform infrared spectroscopy (FTIR) studies revealed the presence of reducing groups in the plant methanolic extract and the functionalization of nanoparticles with BDMCA was also confirmed. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay showed that, the BDMCA-functionalized gold nanocubes possess anticancer activity. The mechanism of action is discussed.

【 授权许可】

CC BY