Insulin plant (Costus pictus) extract improves insulin sensitivity and ameliorates atherogenic dyslipidaemia in fructose induced insulin resistant rats: Molecular mechanism

Journal of Functional Foods

Manoj Joseph¹  Sajini Elizabeth Jacob²  Zachariah Bobby³  S. Ashwini³  Ramamoorthy Padmapriya³ 

[1] Corresponding author. Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research [JIPMER], Pondicherry 605 006, India. Tel.: [phone];fax: [phone].;Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research [JIPMER], Pondicherry 605 006, India;

关键词: Costus pictus;    Insulin resistance;    Low-grade inflammation;    Leptin;    Resistin;    Insulin plant;   

DOI  :  

来源: DOAJ

【 摘 要 】

The preventative effect of insulin plant (Costus pictus) leaf extract on hyperglycaemia, insulin sensitivity and dyslipidaemia in fructose-fed insulin resistant rats was investigated in the present study, further the possible underlying mechanism was also explored. It was observed that under insulin resistant condition this plant extract decreases hyperinsulinaemia by improving insulin sensitivity at the peripheral level through its antioxidant and anti-inflammatory effects. At molecular level decreased activation of molecules involved in stress sensitive signalling cascade and down regulation of pro-inflammatory cytokines were noticed. Furthermore the effects of this plant extract on adipokine profile and plasma homocysteine were evaluated. The possible active components responsible for the beneficial effect exerted by this plant extract have also been identified and quantified. To the best of our knowledge this is the first study on insulin plant extract on the aforementioned animal model.

【 授权许可】

Unknown