Effect of including historical height and radius BMD measurement on sarco‐osteoporosis prevalence

Journal of Cachexia, Sarcopenia and Muscle

Buehring Bjoern¹  Krueger Diane¹ 

[1] University of Wisconsin Osteoporosis Clinical Research Program, Madison, WI

关键词: Sarcopenia;    Osteoporosis;    Age;    Radius BMD;    Sarco-osteoporosis;   

DOI  :  10.1007/s13539-012-0080-8

来源: Wiley

【 摘 要 】

Abstract

Background

A clinical need exists to improve identification of those who will sustain fragility fractures. Individuals with both osteoporosis (OP) and sarcopenia (SP), so-called “sarco-osteoporosis” (SOP), might be at higher fracture risk than those with OP or SP alone. Approaches to facilitate SOP identification, e.g., use of tallest historical rather than current height and inclusion of radius bone mineral density (BMD) measurement, may be of benefit. This study examined the effect of advancing age on SOP prevalence with and without use of historical tallest height and radius BMD measurement.

Methods

Adults age 60+ underwent dual-energy X-ray absorptiometry (DXA) BMD and total body composition measurement. OP and SP were defined using standard criteria: T-score ≤−2.5 at the lumbar spine or hip and appendicular lean mass (ALM)/current height² <5.45 kg/m² (female) and <7.26 kg/m² (male). Proposed “sensitive” SP criteria used historical tallest height instead of current height, while “sensitive” OP criteria added the 1/3^rd radius T-score. The primary outcome was SOP prevalence by decade (60–69, 70–79, 80+).

Results

A total of 304 individuals (146 M/158 F) participated. OP, SP and SOP prevalence were higher in older adults and increased (p < 0.05) with the “sensitive” criteria. SOP prevalence was lower than that of OP or SP and increased (standard/sensitive) criteria from 1.1 % / 4.5 % in the 60–69 years age group to 10.4 % / 21.9 % in the 80+ years age group.

Conclusions

SOP prevalence is higher in older adults. Use of historical tallest height and 1/3^rd radius BMD increases SOP prevalence. Future studies need to assess whether having SOP increases fracture risk and whether use of tallest height and/or one-third radius BMD improves fracture risk prediction.

【 授权许可】

CC BY-NC   
© 2013 The Authors. Published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders

Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.