Diagnostic criteria for acute‐onset type 1 diabetes mellitus (2012): Report of the Committee of Japan Diabetes Society on the Research of Fulminant and Acute‐onset Type 1 Diabetes Mellitus

Journal of Diabetes Investigation

Eiji Kawasaki²  Taro Maruyama¹⁰  Akihisa Imagawa⁸  Takuya Awata⁵  Hiroshi Ikegami¹²  Yasuko Uchigata⁷  Haruhiko Osawa⁶  Yumiko Kawabata¹²  Tetsuro Kobayashi⁴  Akira Shimada¹¹  Ikki Shimizu^2,3  Kazuma Takahashi^2,9  Masao Nagata^2,13  Hideichi Makino^1,2 

[1] Diabetes Center, Shiraishi Hospital, Ehime, Japan;Department of Metabolism/Diabetes and Clinical Nutrition, Nagasaki University Hospital, Nagasaki, Japan;Department of Internal Medicine, The Sakakibara Heart Institute of Okayama, Okayama, Japan;Third Department of Internal Medicine, University of Yamanashi, Yamanashi, Japan;Department of Endocrinology and Diabetes, Saitama Medical University, Saitama, Japan;Department of Laboratory Medicine, Ehime University School of Medicine, Ehime, Japan;Diabetes Center, Tokyo Women's Medical University School of Medicine, Tokyo, Japan;Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan;Department of Diabetes and Metabolism, Iwate Medical University, Iwate, Japan;Department of Internal Medicine, Saitama Social Insurance Hospital, Saitama, Japan;Department of Internal Medicine, Saiseikai Central Hospital, Tokyo, Japan;Department of Endocrinology, Metabolism and Diabetes, Kinki University School of Medicine, Osaka, Japan;Department of Internal Medicine, Kakogawa West City Hospital, Hyogo, Japan

关键词: Criteria;    Diagnosis;    Type 1 diabetes;   

DOI  :  10.1111/jdi.12119

来源: Wiley

【 摘 要 】

Abstract

Type 1 diabetes is a disease characterized by destruction of pancreatic β-cells, which leads to absolute deficiency of insulin secretion. Depending on the manner of onset and progression, it is classified as fulminant, acute-onset or slowly progressive type 1 diabetes. Here, we propose the diagnostic criteria for acute-onset type 1 diabetes mellitus. Among the patients who develop ketosis or diabetic ketoacidosis within 3 months after the onset of hyperglycemic symptoms and require insulin treatment continuously after the diagnosis of diabetes, those with anti-islet autoantibodies are diagnosed with ‘acute-onset type 1 diabetes mellitus (autoimmune)’. In contrast, those whose endogenous insulin secretion is exhausted (fasting serum C-peptide immunoreactivity <0.6 ng/mL) without verifiable anti-islet autoantibodies are diagnosed simply with ‘acute-onset type 1 diabetes mellitus’. Patients should be reevaluated after certain periods in case their statuses of anti-islet autoantibodies and/or endogenous insulin secretory capacity are unknown.

【 授权许可】

CC BY-NC-ND   
© 2013 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and Wiley Publishing Asia Pty Ltd

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