Fulminant type 1 diabetes mellitus: a case report

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Yunir, E.^1 ; Nenfiati^1

Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, CiptoMangunkusumo National General Hospital, Jakarta, Indonesia^1

关键词: Blood glucose;    Blood glucose controls;    Glycosylated hemoglobins;    Insulin injections;    Liver functions;    Metabolic disease;    Type 1 diabetes;    Type 1 diabetes mellitus;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012173/pdf
DOI  :  10.1088/1755-1315/125/1/012173

来源: IOP

【 摘 要 】

Type 1 diabetes mellitus is a metabolic disease caused by insulin deficiency that results from destruction of β-cells in the pancreas. Based on American Diabetes Association, there are two types of type 1 diabetes mellitus: type 1A (autoimmune) and 1B (idiopathic). In this case, we are presenting a new archetype of type 1 diabetes named fulminant type 1 diabetes mellitus. This disease results from quick destruction of β-cells byanautoimmune mechanism. The manifestation of this disease consists of unspecific flu-like symptoms, abdominal symptoms, to specific hyperglycemia symptoms such as fatigue, malaise, change in mental status that are attributable to high blood glucose and ketosis. Laboratory examination reveals high blood glucose, normal glycosylated hemoglobin, ketosis or ketoacidosis, potassium depletion and elevation of liver function tests. Treatment consists of intravenous infusion followed by insulin injection for blood glucose control, followed by treatment of metabolic derangements such as acid-base and electrolyte disorder.