Association of vitamin D3 with alveolar bone regeneration in dogs

Journal of Cellular and Molecular Medicine

Hsiang-Hsi Hong²  Tzung-Hai Yen³  Adrienne Hong¹ 

[1] Department of Integrative Biology, University of California, Berkeley, CA, USA;Department of Periodontics, Chang Gung Memorial Hospital and Chang Gung University, Linkou, Taiwan;Department of Nephrology and Division of Clinical Toxicology, Chang Gung Memorial Hospital and Chang Gung University, Linkou, Taiwan

关键词: alloplast;    bone regeneration;    calcitriol;    cholecalciferol;    vitamin D3;    ridge preservation;   

DOI  :  10.1111/jcmm.12460

来源: Wiley

【 摘 要 】

Abstract

Designed sockets prepared on the mandibles of nine Beagle dogs were divided into three groups: Calcitriol +Alloplast, Alloplast and Empty. Five of the nine dogs received Vit.D₃ and calcium supplement (Vit.D/Ca group), while the other four dogs without supplements were assigned to Non-Vit.D/Ca group. After 4 weeks, the extent of vertical ridge resorption (VRR), bone density (density), new bone formation (NBF) and implant stability quotient (ISQ) were measured. Following systemic Vit.D/Ca administration, the Empty subgroup showed significant differences from the Calcitriol + Alloplast subgroup on variants NBF/Density/VRR and the Alloplast subgroup on items NBF/Density/ISQ/VRR. Alternatively, the Calcitriol + Alloplast subgroup revealed higher values of NBF/Density/ISQ (P < 0.001) and a lower VRRvalue (P = 0.001) than the Alloplast subgroup. Although there were no significant differences in NBF (P = 0.349), density (P = 0.796), ISQ (P = 0.577) and VRR (0.979) comparisons on alloplast treatment between the Vit.D/Ca and Non-Vit.D/Ca groups, local application with Calcitriol + Alloplast demonstrated better NBF/Density/ISQ (P = 0.02 to <0.001) effects than which of Alloplast subgroups. Consequently, the results showed that both systemic and local vitamin D₃ treatment might accelerate bone regeneration in dogs. Within the using dose, systemic vitamin D₃ treatment displayed a superior stimulating effect than local vitamin D₃ application did.

【 授权许可】

CC BY   
© 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

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