ROLE OF VITAMIN D SUPPLEMENTATION IN THE PREVENTION OF INFECTION AND SEVERE COURSE IN COVID-19: TESTING THE HYPOTHESIS

Central Asian Journal of Medical Hypotheses and Ethics

NehaGoyal¹  MohitGoyal² 

[1] Division of Interventional Pain Management, CARE Pain & Arthritis Centre, Goyal Hospital, Udaipur, India;Division of Rheumatology and Clinical Immunology, CARE Pain & Arthritis Centre, Goyal Hospital, Udaipur, India;

关键词: coronavirus disease 2019;    severe acute respiratory syndrome coronavirus 2;    pandemic;    cholecalciferol;    calcitriol;    clinical trial;    vitamin d;    hypothesis;   

DOI  :  10.47316/cajmhe.2021.2.3.03

来源: DOAJ

【 摘 要 】

The coronavirus disease 2019 (COVID-19) pandemic has disrupted the normal activities of various settings, including clinics, laboratories, and libraries. As the world deals with the fast-mutating causative virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), apart from the search for the best vaccine candidate, efforts towards repurposing existing molecules to save lives must continue. Considerable interest has centered around the implications of vitamin D deficiency and its supplementation on the outcomes in patients with COVID-19. We hypothesize that vitamin D supplementation has the potential to confer protection against SARS-CoV-2 infection and a severe COVID-19 course. Various animal, human observational as well as interventional studies have shown a protective role of vitamin D in COVID-19. More robustly designed studies where vitamin D is supplemented prophylactically and administered to those already infected are needed to determine the precise contribution of this supplementation in preventing SARS-CoV-2 infection and modifying the course of COVID-19.

【 授权许可】

Unknown