Pancreatic cancer tumour initiating cells: the molecular regulation and therapeutic values

Journal of Cellular and Molecular Medicine

Xiaoling Ni¹  Jiang Long³  Putao Cen²  Leon Chen¹  Jingxuan Yang¹ 

[1] The Vivian L. Smith Department of Neurosurgery, The University of Texas Health Science Center at Houston, Medical School, Houston, TX, USA;Department of Internal Medicine, Division of Oncology, The University of Texas Health Science Center at Houston, Medical School, Houston, TX, USA;Department of Pancreas & Hepatobiliary Surgery, Shanghai Cancer Center, Shanghai, China

关键词: tumour initiating cells;    microRNA;    pancreatic cancer;   

DOI  :  10.1111/j.1582-4934.2011.01478.x

来源: Wiley

【 摘 要 】

Abstract

• • Introduction
• • Surface markers of pancreatic TICs
• • Signalling pathways in pancreatic TICs
• • Function of microRNAs in TICs regulation, self-renewal and differentiation
• • New therapies targeting the deregulated pathways and miRNAs to treat TICs in pancreatic cancer
• • Conclusion

Pancreatic cancer is an aggressive solid tumour characterized by its local invasion, early metastasis and resistance to standard chemotherapy or radiation therapy. Tumour initiating cells (TICs) are not only capable of self-renewal and differentiation, but also play an important role in multi-drug resistance, and thus become a popular topic in cancer research especially in pancreatic cancer. In this review, we summarize the current progress of TICs in tumourigenesis, various newly identified surface markers of pancreatic TICs, and the signalling pathways such as epithelial-mesenchymal transition, sonic hedgehog and Notch that regulate TICs. We also discuss the role which microRNA plays in TICs as well as its application in TIC-targeted therapy along with other approaches.

【 授权许可】

Unknown   
© 2012 The Authors Journal of Cellular and Molecular Medicine © 2012 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd