Role of MicroRNAs-221/222 in Digestive Systems

Journal of Clinical Medicine

Juntaro Matsuzaki³  Hidekazu Suzuki¹  Takahiro Ochiya² 

[1] Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan;Center for Preventive Medicine, Keio University Hospital, Tokyo 160-0016, Japan; E-Mail;Center for Preventive Medicine, Keio University Hospital, Tokyo 160-0016, Japan; E-Mail:

关键词: microRNA;    colorectal cancer;    hepatocellular carcinoma;    pancreatic cancer;   

DOI  :  10.3390/jcm4081566

来源: mdpi

【 摘 要 】

MiR-221 and miR-222 (miR-221/222) are well-studied oncogenic microRNAs that are frequently upregulated in several types of human tumors, such as esophageal adenocarcinoma, gastric adenocarcinoma, colorectal adenocarcinoma, hepatocellular carcinoma, and pancreatic ductal adenocarcinoma. In these cancers, silencing miR-221/222 could represent a novel anti-tumor approach to inhibit tumor growth and metastasis. On the other hand, miR-221/222 also play onco-suppressive roles in cholangiocarcinoma and gastrointestinal stromal tumors (GISTs). Here we will review the roles of miR-221/222 in digestive systems and their possibility as prognostic and therapeutic tools.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.