The proportion of CD16+CD14dim monocytes increases with tumor cell load in bone marrow of patients with multiple myeloma

Immunity, Inflammation and Disease

Sponaas, Anne M.²  Moen, Siv H.²  Liabakk, Nina B.¹  Feyzi, Emadoldin²  Holien, Toril²  Kvam, Solveig²  Grøseth, Lill Anny G.²  Størdal, Berit²  Buene, Glenn²  Espevik, Terje²  Waage, Anders²  Standal, Therese²  Sundan, Anders² 

[1] K.G. Jebsen Center for Myeloma Research Trondheim Norway

关键词: Apoptosis;    bone marrow;    multiple myeloma;    monocytes;   

DOI  :  10.1002/iid3.53

来源: Wiley

【 摘 要 】

Abstract

Multiple myeloma is an incurable cancer with expansion of malignant plasma cells in the bone marrow. Previous studies have shown that monocytes and macrophages in the bone marrow milieu are important for tumor growth and may play a role in the drug response. We therefore characterized monocytes in bone marrow aspirates by flow cytometry. We found that there was significant correlation between the proportion of CX₃CR₁⁺, CD16⁺CD14^dim non classical monocytes, and percent plasma cells (PC) in the bone marrow of myeloma patients. The bone marrow monocytes could be stimulated by TLR ligands to produce cytokines which promote myeloma cell growth. The proportion of the non-classical monocytes increased with the tumor load, particularly in patients with tumor loads in the range of 10–30% bone marrow PC.

【 授权许可】

CC BY   
© 2015 The Authors. Immunity, Inflammation and DiseasePublished by John Wiley & Sons Ltd.

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