Multiple myeloma is an incurable cancer with expansion of malignant plasma cells in the bone marrow. Previous studies have shown that monocytes and macrophages in the bone marrow milieu are important for tumor growth and may play a role in the drug response. We therefore characterized monocytes in bone marrow aspirates by flow cytometry. We found that there was significant correlation between the proportion of CX3CR1+, CD16+CD14dim non classical monocytes, and percent plasma cells (PC) in the bone marrow of myeloma patients. The bone marrow monocytes could be stimulated by TLR ligands to produce cytokines which promote myeloma cell growth. The proportion of the non-classical monocytes increased with the tumor load, particularly in patients with tumor loads in the range of 10–30% bone marrow PC.
期刊论文详细信息
Immunity, Inflammation and Disease | |
The proportion of CD16+CD14dim monocytes increases with tumor cell load in bone marrow of patients with multiple myeloma | |
Sponaas, Anne M.2  Moen, Siv H.2  Liabakk, Nina B.1  Feyzi, Emadoldin2  Holien, Toril2  Kvam, Solveig2  Grøseth, Lill Anny G.2  Størdal, Berit2  Buene, Glenn2  Espevik, Terje2  Waage, Anders2  Standal, Therese2  Sundan, Anders2  | |
[1] K.G. Jebsen Center for Myeloma Research Trondheim Norway | |
关键词: Apoptosis; bone marrow; multiple myeloma; monocytes; | |
DOI : 10.1002/iid3.53 | |
来源: Wiley | |
【 摘 要 】
Abstract
【 授权许可】
CC BY
© 2015 The Authors. Immunity, Inflammation and DiseasePublished by John Wiley & Sons Ltd.
Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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