Capturing the Fantastic Voyage of Monocytes Through Time and Space

Frontiers in Immunology

卷:10

Lai Guan Ng¹  Ye Chean Teh²  Jeak Ling Ding²  Shu Zhen Chong⁵ 

[1] Immunology, Immunology Programme, Life Science Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;

[2] Department of Biological Sciences, National University of Singapore (NUS), Singapore, Singapore;

[3] Department of Microbiology &

[4] Functional Immune Imaging, Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore;

[5] School of Biological Sciences, Nanyang Technological University, Singapore, Singapore;

关键词: monocytes;    marginal pool;    bone marrow;    spleen;    CXCR4 = chemokine receptor 4;    inflammation;   

DOI  :  10.3389/fimmu.2019.00834

来源: DOAJ

【 摘 要 】

Monocytes are a subset of cells that are categorized together with dendritic cells (DCs) and macrophages in the mononuclear phagocyte system (MPS). Despite sharing several phenotypic and functional characteristics with MPS cells, monocytes are unique cells with the ability to function as both precursor and effector cells in their own right. Before the development of hematopoietic stem cells (HSCs) in utero, monocytes are derived from erythro-myeloid precursors (EMPs) in the fetal liver that are important for populating the majority of tissue resident macrophages. After birth, monocytes arise from bone marrow (BM)-derived HSCs and are released into the circulation upon their maturation, where they survey peripheral tissues and maintain endothelial integrity. Upon sensing of microbial breaches or inflammatory stimuli, monocytes migrate into tissues where their plasticity allows them to differentiate into cells that resemble macrophages or DCs according to the environmental niche. Alternatively, they may also migrate into tissues in the absence of inflammation and remain in an undifferentiated state where they perform homeostatic roles. As monocytes are typically on the move, the availability of intravital imaging approaches has provided further insights into their trafficking patterns in distinct tissue compartments. In this review, we outline the importance of understanding their functional behavior in the context of tissue compartments, and how these studies may contribute towards improved vaccine and future therapeutic strategies.

【 授权许可】

Unknown