Investigation into the prevalence of a novel dendritic‐like cell subset in vivo

Journal of Cellular and Molecular Medicine

Kristin Lisa Griffiths¹  Jonathan Kah Huat Tan¹ 

[1] Research School of Biology, The Australian National University, Acton, ACT, Australia

关键词: Dendritic cells;    cross‐presentation;    spleen;    bone marrow;   

DOI  :  10.1111/jcmm.12174

来源: Wiley

【 摘 要 】

Abstract

A novel dendritic-like cell subset termed L-DC was recently identified in murine spleen based on marker expression of a homogeneous cell population derived from long-term culture of neonatal spleen. The function of L-DC is distinct from other splenic dendritic and myeloid cell subsets because of their high endocytic capacity and their ability to cross-present antigen to CD8⁺ T cells. This paper shows the subset to be unique to spleen and blood, with a similar, but possibly functionally distinct subset also present in bone marrow. The prevalence of the subset is low; ~6% of all dendritic and myeloid cells in the spleen and ~5% in blood. However, they are a distinct cell type on the basis of marker expression, and endocytic and T-cell stimulatory capacity. Attempts to identify an enriched population of these cells in mutant mouse strains with reported increases in myelopoiesis showed either a lack of L-DC or an altered phenotype reflective of the phenotype of the mouse strain.

【 授权许可】

CC BY   
© 2013 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.