Effect of Physiological Determinants and Cardiac Disease on Plasma Adiponectin Concentrations in Dogs

Journal of Veterinary Internal Medicine

C. Damoiseaux¹  A.-C. Merveille¹  E. Krafft¹  A.M. Da Costa²  S. Gomart²  P. Jespers²  C. Michaux³  C. Clercx¹  C. Verhoeven⁴ 

[1] Department of Small Animal Clinical Sciences, Faculty of Veterinary Medicine, Université de Liège, Liège, Belgium;Laboratory of Physiology, Faculty of Medicine, Université Libre de Bruxelles, Brussels, Belgium;Laboratory of Anatomy, Faculty of Medicine, Université Libre de Bruxelles, Brussels, Belgium;Biostatistics and Medical Informatics Unit, Faculty of Medicine, Université Libre de Bruxelles, Brussels, Belgium

关键词: Adipokines;    Age;    Dilated cardiomyopathy;    Myxomatous mitral valve disease;    Neuter status;   

DOI  :  10.1111/jvim.12433

来源: Wiley

【 摘 要 】

Abstract

Background

In humans, a high concentration of adiponectin is associated with a favorable cardiovascular risk profile whereas, in patients with heart failure (HF), a high concentration of adiponectin is associated with a less favorable prognosis.

Hypothesis/Objectives

To evaluate the physiological determinants of plasma adiponectin concentration in dogs and the influence of heart disease, myxomatous mitral valve disease (MMVD), and dilated cardiomyopathy (DCM).

Animals

One hundred and fourteen client-owned dogs and 9 Beagles from the research colony of the Clinical Veterinary Unit of the University of Liège.

Methods

We prospectively measured circulating adiponectin concentration in healthy control dogs (n = 77), dogs with MMVD (n = 22) and dogs with DCM (n = 15) of various degrees of severity. Diagnosis was confirmed by Doppler echocardiography. Plasma adiponectin concentration was measured by a canine-specific sandwich ELISA kit.

Results

An analysis of covariance showed an association between adiponectin concentration and age, neuter status, and heart disease. No association between adiponectin concentration and class of HF, sex, body condition score, body weight, circadian rhythm, or feeding was found. Plasma adiponectin concentration was negatively correlated with age (P = .001). Adiponectin was lower in neutered (P = .008) compared to intact dogs. Circulating adiponectin concentration was increased in dogs with DCM compared to healthy dogs (P = .018) and to dogs with MMVD (P = .014).

Conclusions and Clinical Importance

Age and neutering negatively influence circulating adiponectin concentration. Plasma adiponectin concentration increased in dogs with DCM. Additional research is required to investigate if this hormone is implicated in the pathophysiology of DCM and associated with clinical outcome.

【 授权许可】

Unknown   
Copyright © 2014 by the American College of Veterinary Internal Medicine