Advanced Electrocardiographic Parameters Change with Severity of Mitral Regurgitation in Cavalier King Charles Spaniels in Sinus Rhythm

Journal of Veterinary Internal Medicine

M. Špiljak Pakkanen⁴  A. Domanjko Petrič³  L.H. Olsen¹  A. Stepančič²  T.T. Schlegel⁵  T. Falk⁶  C.E. Rasmussen⁶ 

[1] Department of Veterinary Disease Biology, Faculty of Life Sciences, (Olsen);Quality Control Department, Metallurgical and Chemical Industry Cinkarna Celje, Inc., Celje, Slovenia (Stepančič);Clinic for Surgery and Small Animal Medicine, Veterinary Faculty, University of Ljubljana, Ljubljana, Slovenia (Domanjko Petrič);Institute of Physiology, Medical Faculty, Ljubljana, (Špiljak Pakkanen, Starc);Human Adaptation and Countermeasures Division, NASA Johnson Space Center, Houston, Texas (Schlegel);Department of Animal and Veterinary Sciences, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark (Falk, Rasmussen)

关键词: Advanced ECG;    Cardiac disease;    Dog;    Screening;   

DOI  :  10.1111/j.1939-1676.2011.00845.x

来源: Wiley

【 摘 要 】

Abstract

Background

Multiple advanced resting ECG (A-ECG) techniques have improved the diagnostic or prognostic value of ECG in detecting human cardiac diseases even before onset of clinical signs or changes in conventional ECG.

Objective

To determine which A-ECG parameters, derived from 12-lead A-ECG recordings, change with severity of mitral regurgitation (MR) caused by myxomatous mitral valve disease (MMVD) in Cavalier King Charles Spaniels (CKCSs) in sinus rhythm.

Animals

Seventy-six privately owned CKCSs.

Methods

Dogs were prospectively divided into 5 groups according to the degree of MR (estimated by color Doppler mapping as the percentage of the left atrial area affected by the MR jet) and presence of clinical signs. High fidelity approximately 5-minute 12-lead ECG recordings were evaluated using custom software to calculate multiple conventional and A-ECG parameters.

Results

Nineteen of 76 ECG parameters were significantly different (P < .05) across the 5 dog groups. A 4-parameter model that incorporated results from 1 parameter of heart rate variability, 2 parameters of QT variability, and 1 parameter of QRS amplitude was identified that explained 82.4% of the variance with a correlation coefficient (R) of 0.60 (P < .01). When age or murmur grade was included in the statistical model the prediction value further increased the R to 0.74 and 0.85 (P < .01), respectively.

Conclusion

In CKCSs with sinus rhythm, 4 selected A-ECG parameters further improve prediction of MR jet severity beyond age and murmur grade, although the predictive increment in this study probably is not sufficient to warrant utilization in clinical veterinary practice.

【 授权许可】

Unknown   
Copyright © 2011 by the American College of Veterinary Internal Medicine