The prevalence of pulmonary hypertension assessed using the pulmonary vein‐to‐right pulmonary artery ratio and its association with survival in West Highland white terriers with canine idiopathic pulmonary fibrosis

BMC Veterinary Research

Erik Teske¹  Géraldine Bolen²  Anne-Christine Merveille²  Aline Fastrès²  Cécile Clercx²  Elodie Roels³  Kathleen Mc Entee⁴ 

[1] Department of Clinical Sciences of Companion Animals, Faculty of Medicine, Utrecht University, 3584 CL, Utrecht, The Netherlands;Department of Clinical Sciences, Faculty of Veterinary Medicine, FARAH, University of Liege, 4000, Liege, Belgium;Department of Internal Medicine, Pride Veterinary Centre, DE24 8HX, Derby, United Kingdom;Laboratory of Physiology and Pharmacology, Faculty of Medicine, Université Libre de Bruxelles, 1070, Brussels, Belgium;

关键词: Dog;    Cardiac disease;    Echocardiography;    Pulmonary arterial pressure;    Tricuspid regurgitation;   

DOI  :  10.1186/s12917-021-02879-w

来源: Springer

【 摘 要 】

BackgroundPulmonary hypertension (PH) is a known co-morbidity in West Highland white terriers (WHWTs) affected with canine idiopathic pulmonary fibrosis (CIPF). The pulmonary vein-to-right pulmonary artery ratio (PV/PA) has recently been described for the detection of pre-capillary PH in dogs. The objective of the present study was to estimate the prevalence of PH at diagnostic, in WHWTs affected with CIPF, by using PV/PA, in comparison with a group of healthy breed-matched controls (CTRLs). Additional study objective was to explore whether the presence of PH at initial diagnosis of CIPF impacted survival time in dogs treated with sildenafil.ResultsTwenty-five client-owned WHWTs presented with CIPF and 19 CTRLs were included in the study. PV/PA in either two-dimensional mode (2D) or time-motion mode or both were measured from cineloops in each dog. Dogs were classified according to PV/PA value into non/mild PH (PV/PA measured in 2D ≥ 0.7) or moderate/severe PH (PV/PA < 0.7). Survival data of WHWTs affected with CIPF were extracted from medical record to assess association between presence of PH at diagnosis and outcome. 60 % overall prevalence for moderate/severe PH was estimated in this cohort of WHWTs presented with CIPF vs. 5 % in CTRLS (P = 0.0002). The presence of moderate/severe PH at initial presentation was not associated with survival.ConclusionsResults of the present study confirm a high prevalence of PH at diagnosis in WHWTs affected with CIPF and highlight the utility of PV/PA as a non-invasive surrogate for assessment of PH in this population.

【 授权许可】

CC BY