Pregnant mice lacking indoleamine 2,3‐dioxygenase exhibit preeclampsia phenotypes

Physiological Reports

Mark K. Santillan⁴  Christopher J. Pelham²  Pimonrat Ketsawatsomkron²  Donna A. Santillan⁴  Deborah R. Davis²  Eric J. Devor⁴  Katherine N. Gibson-Corley³  Sabrina M. Scroggins⁴  Justin L. Grobe¹  Baoli Yang⁴  Steven K. Hunter⁴ 

[1] The Center for Hypertension Research, University of Iowa, Iowa City, Iowa;Department of Pharmacology, University of Iowa, Iowa City, Iowa;Department of Pathology, University of Iowa, Iowa City, Iowa;Department of Obstetrics & Gynecology, University of Iowa, Iowa City, Iowa

关键词: Animal model;    indoleamine 2;    3‐dioxygenase;    preeclampsia;    T cell;   

DOI  :  10.14814/phy2.12257

来源: Wiley

【 摘 要 】

Abstract

Preeclampsia is a cardiovascular disorder of late pregnancy that is, commonly characterized by hypertension, renal structural damage and dysfunction, and fetal growth restriction. Prevailing etiologic models of this disorder include T-cell dysfunction as an initiating cause of preeclampsia. Indoleamine 2,3-dioxygenase (IDO), an enzyme that mediates the conversion of tryptophan to kynurenine, has been linked to preeclampsia in humans, and is known to regulate T-cell activity and an endothelial-derived relaxing factor. To test the hypothesis that IDO is causally involved in the pathogenesis of preeclampsia, mice deficient for IDO (IDO-KO) were generated on a C57BL/6 background. IDO-KO and wild-type C57BL/6 mice were bred, and preeclampsia phenotypes were evaluated during pregnancy. Pregnant IDO-KO mice exhibited pathognomonic renal glomerular endotheliosis, proteinuria, pregnancy-specific endothelial dysfunction, intrauterine growth restriction, and mildly elevated blood pressure compared to wild-type mice. Together these findings highlight an important role for IDO in the generation of phenotypes typical of preeclampsia. Loss of IDO function may represent a risk factor for the development of preeclampsia. By extension, increased IDO activity, reductions in IDO reactants, or increases in IDO products may represent novel therapeutic approaches for this disorder.

【 授权许可】

CC BY   
© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.