A case of CLL that was successfully treated resulted in the immediate development of AML from a coexistent myeloid line that had been suppressed

Clinical Case Reports

Mohammad Ansari¹  Michael Auerbach¹ 

[1] Auerbach Hematology-Oncology Associates, Baltimore, Maryland

关键词: Acute myeloid leukemia;    chronic lymphocytic leukemia;    cytogenetics;    FISH;    flow cytometry;    peripheral smear;    bone marrow examination;   

DOI  :  10.1002/ccr3.184

来源: Wiley

【 摘 要 】

Key Clinical Message

An 83 year-old Caucasian male presented to the emergency room with confusion and lethargy. A complete blood count revealed lymphocytosis, anemia, and thrombocytopenia. A bone marrow examination revealed chronic lymphocytic leukemia (CLL), along with a small population of abnormal immature myeloid cells. Chemotherapy for CLL was started. After one cycle, repeat bone marrow examination revealed normalization of the lymphocyte count and a proliferation of the previously noted myeloid population, consistent with acute myeloid leukemia (AML). This report presents the microscopic, immunophenotypic, and cytogenetic evidence to document the development of AML after one cycle of chemotherapy for CLL.

【 授权许可】

CC BY-NC   
© 2014 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.

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