Increased eculizumab requirements during pregnancy in a patient with paroxysmal nocturnal hemoglobinuria: case report and review of the literature

Clinical Case Reports

Christopher Patriquin¹  Brian Leber¹ 

[1] Division of Hematology & Thromboembolism, Department of Medicine, Juravinski Hospital and Cancer Centre, Hamilton, Ontario, Canada

关键词: Aplastic anemia;    eculizumab;    hemolysis;    PNH;    pregnancy;   

DOI  :  10.1002/ccr3.161

来源: Wiley

【 摘 要 】

Key Clinical Message

Paroxysmal nocturnal hemoglobinuria (PNH) results from reduced complement regulatory proteins on hematopoietic cells, predisposing patients to intravascular hemolysis, thrombophilia, and cytopenias. Women diagnosed in pregnancy can experience significant maternofetal complications. Trials of eculizumab in PNH excluded pregnant women. Here, we report the first Canadian patient taken through pregnancy on eculizumab.

【 授权许可】

CC BY-NC   
© 2014 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.

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