Decreased expression of FcγRIII mRNA in leukemic granulocytes

FEBS Letters

Monteiro, Joanita²  Gothoskar, Balwant²  Zingde, Surekha²  Advani, Suresh¹ 

[1] Tata Memorial Hospital, Parel, Bombay 400 012, India;Cancer Research Institute, Parel, Bombay 400 012, India

关键词: FcγRIII;    Leukemic;    Granulocyte;    CML;    chronic myeloid leukemia;    PI;    phosphatidyl-inositol;    PNH;    paroxysmal nocturnal hemoglobinuria;   

DOI  :  10.1016/0014-5793(92)80174-F

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Morphologically mature granulocytes from patients with chronic myeloid leukemia show significant impairment in their ability to internalize aggregated IgG, a ligand that is rapidly phagocytosed by normal human granulocytes. With a view to understand the molecular basis of this defect, normal and leukemic granulocytes were examined for the steady-state levels of mRNA for FcγRIII, a membrane-associated receptor that initially binds and traps the IgG-opsonized antigens. Northern blot analyses revealed that the level of the specific mRNA in CML granulocytes was between 0.08 and 0.69 times that seen in the normal granulocytes. This could be one of the contributory factors for the observed endocytic defect in the leukemic granulocytes.

【 授权许可】

Unknown