Suprabasin as a novel tumor endothelial cell marker

Cancer Science

Mohammad T. Alam³  Hiroko Nagao-Kitamoto³  Noritaka Ohga³  Kosuke Akiyama³  Nako Maishi³  Taisuke Kawamoto³  Nobuo Shinohara¹  Akinobu Taketomi²  Masanobu Shindoh⁴  Yasuhiro Hida⁵ 

[1] Department of Renal and Genitourinary Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan;Department of Gastroenterological Surgery I, Graduate School of Medicine, Hokkaido University, Sapporo, Japan;Vascular Biology, Frontier Research Unit, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan;Department of Oral Pathology and Biology, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan;Department of Cardiovascular and Thoracic Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan

关键词: Angiogenesis;    suprabasin;    suprabasin signaling;    tumor endothelial cell marker;    tumor endothelial cells;   

DOI  :  10.1111/cas.12549

来源: Wiley

【 摘 要 】

Abstract

Recent studies have reported that stromal cells contribute to tumor progression. We previously demonstrated that tumor endothelial cells (TEC) characteristics were different from those of normal endothelial cells (NEC). Furthermore, we performed gene profile analysis in TEC and NEC, revealing that suprabasin (SBSN) was upregulated in TEC compared with NEC. However, its role in TEC is still unknown. Here we showed that SBSN expression was higher in isolated human and mouse TEC than in NEC. SBSN knockdown inhibited the migration and tube formation ability of TEC. We also showed that the AKT pathway was a downstream factor of SBSN. These findings suggest that SBSN is involved in the angiogenic potential of TEC and may be a novel TEC marker.

【 授权许可】

CC BY-NC-ND   
© 2014 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

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