Exercise‐stimulated interleukin‐15 is controlled by AMPK and regulates skin metabolism and aging

Aging Cell

Justin D. Crane⁴  Lauren G. MacNeil¹  James S. Lally³  Rebecca J. Ford³  Adam L. Bujak³  Ikdip K. Brar¹  Bruce E. Kemp²  Sandeep Raha¹  Gregory R. Steinberg³ 

[1] Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada;Department of Medicine, St. Vincent's Institute of Medical Research, University of Melbourne, Fitzroy, Vic., Australia;Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada;Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada

关键词: aging;    exercise;    muscle;    metabolism;    mitochondria;    skin;   

DOI  :  10.1111/acel.12341

来源: Wiley

【 摘 要 】

Summary

Aging is commonly associated with a structural deterioration of skin that compromises its barrier function, healing, and susceptibility to disease. Several lines of evidence show that these changes are driven largely by impaired tissue mitochondrial metabolism. While exercise is associated with numerous health benefits, there is no evidence that it affects skin tissue or that endocrine muscle-to-skin signaling occurs. We demonstrate that endurance exercise attenuates age-associated changes to skin in humans and mice and identify exercise-induced IL-15 as a novel regulator of mitochondrial function in aging skin. We show that exercise controls IL-15 expression in part through skeletal muscle AMP-activated protein kinase (AMPK), a central regulator of metabolism, and that the elimination of muscle AMPK causes a deterioration of skin structure. Finally, we establish that daily IL-15 therapy mimics some of the anti-aging effects of exercise on muscle and skin in mice. Thus, we elucidate a mechanism by which exercise confers health benefits to skin and suggest that low-dose IL-15 therapy may prove to be a beneficial strategy to attenuate skin aging.

【 授权许可】

CC BY   
© 2015 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.