A Distinct Pattern of Circulating Amino Acids Characterizes Older Persons with Physical Frailty and Sarcopenia: Results from the BIOSPHERE Study

Nutrients

Federico Marini¹  Alessandra Biancolillo¹  Andrea Urbani²  Francesco Landi²  Jacopo Gervasoni²  Riccardo Calvani²  Roberto Bernabei²  Maurizio Bossola²  Emanuele Marzetti²  Anna Picca²  Silvia Persichilli²  HélioJosé Coelho-Junior³  Aniello Primiano³ 

[1] Department of Chemistry, Sapienza University of Rome, Rome 00168, Italy;Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome 00168, Italy;Università Cattolica del Sacro Cuore, Rome 00168, Italy;

关键词: aging;    muscle;    protein;    metabolism;    metabolomics;    profiling;    biomarkers;    multi-marker;    physical performance;    multivariate;   

DOI  :  10.3390/nu10111691

来源: DOAJ

【 摘 要 】

Physical frailty and sarcopenia (PF&S) are hallmarks of aging that share a common pathogenic background. Perturbations in protein/amino acid metabolism may play a role in the development of PF&S. In this initial report, 68 community-dwellers aged 70 years and older, 38 with PF&S and 30 non-sarcopenic, non-frail controls (nonPF&S), were enrolled as part as the “BIOmarkers associated with Sarcopenia and Physical frailty in EldeRly pErsons„ (BIOSPHERE) study. A panel of 37 serum amino acids and derivatives was assayed by UPLC-MS. Partial Least Squares⁻Discriminant Analysis (PLS-DA) was used to characterize the amino acid profile of PF&S. The optimal complexity of the PLS-DA model was found to be three latent variables. The proportion of correct classification was 76.6 ± 3.9% (75.1 ± 4.6% for enrollees with PF&S; 78.5 ± 6.0% for nonPF&S). Older adults with PF&S were characterized by higher levels of asparagine, aspartic acid, citrulline, ethanolamine, glutamic acid, sarcosine, and taurine. The profile of nonPF&S participants was defined by higher concentrations of α-aminobutyric acid and methionine. Distinct profiles of circulating amino acids and derivatives characterize older people with PF&S. The dissection of these patterns may provide novel insights into the role played by protein/amino acid perturbations in the disabling cascade and possible new targets for interventions.

【 授权许可】

Unknown