ATF4 activity: a common feature shared by many kinds of slow‐aging mice

Aging Cell

Weiquan Li¹  Xinna Li¹ 

[1] Department of Pathology, University of Michigan, Ann Arbor, MI, USA

关键词: acarbose;    caloric restriction;    longevity;    methionine restriction;    rapamycin;   

DOI  :  10.1111/acel.12264

来源: Wiley

【 摘 要 】

Summary

ATF4, a DNA-binding factor that modulates responses to amino acid availability and ribosomal function, has been shown to be altered in both liver and fibroblasts from two strains of long-lived mice, i.e. Snell dwarf and PAPP-A knockout mice. New data now show elevated ATF4 levels, and elevation of ATF4-dependent proteins and mRNAs, in liver of mice treated with acarbose or rapamycin, calorically restricted mice, methionine-restricted mice, and mice subjected to litter crowding. Elevation of ATF4, at least in liver, thus seems to be a shared feature of diets, drugs, genes, and developmental alterations that extend maximum lifespan in mice.

【 授权许可】

CC BY   
© 2014 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.