Physiological and Molecular Mechanisms of Methionine Restriction

Frontiers in Endocrinology

Khalid Walid Freij¹  Mary Neslund Latimer¹  Peggy R. Biga¹  Beth M. Cleveland² 

[1] Department of Biology, University of Alabama at Birmingham, Birmingham, AL, United States;National Center for Cool and Cold Water Aquaculture, Agricultural Research Service (USDA), Kearneysville, WV, United States;

关键词: microRNA;    methionine restriction;    stress;    physiological;    caloric restriction;    mechanisms;   

DOI  :  10.3389/fendo.2018.00217

来源: DOAJ

【 摘 要 】

Methionine restriction (MR) has been studied extensively over the last 25 years for its role in altering metabolic hallmarks of disease. Animals subjected to MR, display changes in metabolic flexibility demonstrated by increases in energy expenditure, glucose tolerance, and lifespan. These changes have been well characterized in a number of model systems and significant progress has been made in understanding how hepatic fibroblast growth factor 21 links MR to several components of its metabolic phenotype. Despite these advances, a complete understanding of mechanisms engaged by dietary MR remains elusive. In this review, we offer a brief history of MR and its known mechanisms associated with stress, metabolism, and lifespan extension. We consider the role of epigenetics in the response of animals to MR and propose a novel epigenetic pathway involving the regulation of microRNAs during MR.

【 授权许可】

Unknown