Prolonging the female reproductive lifespan and improving egg quality with dietary omega‐3 fatty acids

Aging Cell

Deepika Nehra²  Hau D. Le²  Erica M. Fallon²  Sarah J. Carlson²  Dori Woods¹  Yvonne A. White¹  Amy H. Pan²  Lankai Guo¹  Scott J. Rodig³  Jonathan L. Tilly¹  Bo R. Rueda¹ 

[1] Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital and Boston, Boston, MA, USA;Department of Surgery and the Vascular Biology Program, Children's Hospital Boston, Boston, MA, USA;Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA

关键词: advanced maternal age;    docosahexaenoic acid;    menopause;    omega‐3 fatty acid;    oocyte;    reproduction;   

DOI  :  10.1111/acel.12006

来源: Wiley

【 摘 要 】

Summary

Women approaching advanced maternal age have extremely poor outcomes with both natural and assisted fertility. Moreover, the incidence of chromosomal abnormalities and birth defects increases with age. As of yet, there is no effective and practical strategy for delaying ovarian aging or improving oocyte quality. We demonstrate that the lifelong consumption of a diet rich in omega-3 fatty acids prolongs murine reproductive function into advanced maternal age, while a diet rich in omega-6 fatty acids is associated with very poor reproductive success at advanced maternal age. Furthermore, even short-term dietary treatment with a diet rich in omega-3 fatty acids initiated at the time of the normal age-related rapid decline in murine reproductive function is associated with improved oocyte quality, while short-term dietary treatment with omega-6 fatty acids results in very poor oocyte quality. Thus, omega-3 fatty acids may provide an effective and practical avenue for delaying ovarian aging and improving oocyte quality at advanced maternal age.

【 授权许可】

Unknown   
© 2012 The Authors Aging Cell © 2012 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland