Relationship of Soluble Interleukin-6 Receptors With Asthma: A Mendelian Randomization Study

Frontiers in Medicine

Yoshihiko Raita¹  Carlos A. Camargo¹  Kohei Hasegawa¹  Zhaozhong Zhu¹  Robert J. Freishtat²  Liming Liang³  Debby Ngo⁴ 

[1] Department of Emergency Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States;Division of Emergency Medicine, Children's National Hospital, Washington, DC, United States;Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC, United States;Department of Genomics and Precision Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, United States;Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States;Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, United States;Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States;

关键词: interleukin-6;    soluble interleukin-6 receptor;    trans-signaling pathway;    asthma;    Mendelian randomization;    GWAS;    UK Biobank;   

DOI  :  10.3389/fmed.2021.665057

来源: Frontiers

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