The Beneficial Effect of Vanillic Acid on Ulcerative Colitis

Molecules

Su-Jin Kim¹  Min-Cheol Kim¹  Jae-Young Um¹ 

[1] ¹Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University Dongdaemun-Gu, Seoul 130-701, Korea ²Wonkwang Oriental Medicines Research Institute, Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk 570-749, Korea ^†These authors contributed equally to this work.

关键词: vanillic acid;    dextran sulfate sodium;    ulcerative colitis;    cyclooxygenase-2;    nuclear factor-κB p65;    interleukin-6;   

DOI  :  10.3390/molecules15107208

来源: mdpi

【 摘 要 】

Vanillic acid, an oxidized form of vanillin, is a benzoic acid derivative used as a flavoring agent. The objective of this study was to determine whether vanillic acid has beneficial effects against dextran sulfate sodium (DSS)-induced ulcerative colitis. Our results showed that vanillic acid reduced the severity of the clinical signs of DSS-induced colitis, including weight loss and shortening of colon length, and the disease activity index. The results of this study showed that vanillic acid significantly suppressed the expression of cyclooxygenase-2 and the activation of transcription nuclear factor-kB p65 in DSS-treated colon tissues. In addition, we observed that the plasma levels of interleukin (IL)-6 were higher in the DSS-treated group than in the control group, but these increased levels were reduced by the administration of vanillic acid. Taken together, these findings suggest that vanillic acid has a beneficial effect on DSS-induced ulcerative colitis, thereby indicating its usefulness in the regulation of chronic intestinal inflammation.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.