Common Variants Associated With OSMR Expression Contribute to Carotid Plaque Vulnerability, but Not to Cardiovascular Disease in Humans

Frontiers in Cardiovascular Medicine

Gerard Pasterkamp¹  Arjan Boltjes¹  Sander W. van der Laan¹  Dennie Tempel²  Folkert W. Asselbergs³  Gert J. de Borst⁴  Ian D. van Koeverden⁵  Danielle van Keulen⁶  Hans M. G. Princen⁷  Alain J. van Gool⁸ 

[1] Central Diagnostics Laboratory, University Medical Center Utrecht, University of Utrecht, Utrecht, Netherlands;Central Diagnostics Laboratory, University Medical Center Utrecht, University of Utrecht, Utrecht, Netherlands;Quorics B.V., Rotterdam, Netherlands;SkylineDx B.V., Rotterdam, Netherlands;Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands;Faculty of Population Health Sciences, Institute of Cardiovascular Science, University College London, London, United Kingdom;Health Data Research UK and Institute of Health Informatics, University College London, London, United Kingdom;Department of Vascular Surgery, University Medical Center Utrecht, University of Utrecht, Utrecht, Netherlands;Laboratory of Experimental Cardiology, University Medical Center Utrecht, University of Utrecht, Utrecht, Netherlands;Laboratory of Experimental Cardiology, University Medical Center Utrecht, University of Utrecht, Utrecht, Netherlands;Central Diagnostics Laboratory, University Medical Center Utrecht, University of Utrecht, Utrecht, Netherlands;Quorics B.V., Rotterdam, Netherlands;TNO-Metabolic Health Research, Gaubius Laboratory, Leiden, Netherlands;TNO-Metabolic Health Research, Gaubius Laboratory, Leiden, Netherlands;Translational Metabolic Laboratory, Radboudumc, Nijmegen, Netherlands;TNO- Microbiology & Systems Biology, Zeist, Netherlands;

关键词: cardiovascular disease;    atherosclerosis;    plaque;    genetics;    OSM;    OSMR;    LIFR;   

DOI  :  10.3389/fcvm.2021.658915

来源: Frontiers

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